What’s Ibutamoren (MK-677) – Side Effects & Dangers

07 Aug What’s Ibutamoren (MK-677) – Side Effects & Dangers

Ibutamoren mesylate (MK-677) arouses hormones, but studies have discovered potential harm and unwanted side effects. Why do people use it? What are the risks? Keep reading to find out.

Disclaimer: By composing this informative article, we are not recommending this drug. A number of our subscribers who were taking the medication requested that we commission a post on it, and we are simply providing information that’s offered in the clinical and clinical literature.

We strongly recommend against accepting ibutamoren for any reason. This drug was never approved for human usage. It is deemed unsafe and inefficient.

What is Ibutamoren?

Growth Hormone Stimulator

Ibutamoren is frequently discussed on online forums because of its muscle properties. It’s available online and used by people wishing to raise their growth hormone levels. Be aware, however, that it is illegal to market ibutamoren for human consumption.

However, clinical trials of the compound are few. Below we will highlight the current knowledge about ibutamoren.

Ibutamoren (also referred to as ibutamoren mesylate or MK-677), is thought to promote the secretion of the growth hormone (GH) and increase insulin-like development factor 1 (IGF-1).

Ibutamoren possibly increases growth hormone levels by mimicking the activity of the hormone ghrelin and transmitting to one of those ghrelin receptors (GHSR) from the brain. Activated GHSR stimulates growth hormone release from the mind.

GHSR can be found in brain areas that control hunger, mood, pleasure, biological rhythms, memory, and cognition.

Therefore, some people today expect that ibutamoren may also impact these functions. But so far, clinical studies describe just the ramifications ibutamoren has on appetite — and as expected, like ghrelin, ibutamoren increases it.

According to some research, ibutamoren could potentially increase growth hormone levels with very little if any increase in other hormones, such as cortisol. Cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it is usually not good to have this hormone elevated.

Ibutamoren is an unapproved medication that may increase testosterone hormone and IGF-1. It is thought to have no effect on other hormones like cortisol.

Snapshot

Proponents:

• Boosts growth hormone
• May increase lean body mass and enhance fat burning
• Strengthens the bones
• Can enhance sleep quality
• May encourage cognition and longevity

Skeptics:

• Not approved for human usage
• Probably to become dangerous for human consumption
• May cause swelling and muscle pain
• May increase blood sugar and cause insulin resistance
• May raise blood pressure and lead to heart failure
• Dangerous for cancer sufferers
• Potential side effects

Why Some People Today Use Ibutamoren

Recall that none of the following uses are backed up by adequate clinical studies. Almost all of these factors derive from a proposed increase in growth hormone; people assume that ibutamoren increases the effects of growth hormone, as well.

However, due to the shortage of study and insufficient security data, we believe you are better off talking to a doctor regarding approved growth hormone medication or lifestyle & nutritional supplement changes that were proven to increase growth hormone.

We strongly suggest that you don’t require ibutamoren for any purpose. It has already been shown to have dangerous side effects, and more adverse effects may nevertheless be discovered.

1) Muscle Building

Ibutamoren is frequently employed as an anabolic chemical, to increase lean body mass — in other words, to create bigger muscles. It’s orally active and may be taken once each day.

As previously mentioned, ibutamoren may increase growth hormone amounts and IGF-1. Both growth hormone and IGF-1, in turn, increase muscle mass, muscle strength, and decrease body fat.

In 24 obese guys, a two-month treatment with ibutamoren improved lean mass, and transiently increased basal metabolic rate (BMR).

By boosting growth hormone and IGF-1, ibutamoren may increase muscle mass and decrease body fat. It is popular among bodybuilders and could be taken orally. But, its purported benefits are unproven, and it could be unsafe.

2) Encourages Muscle Wasting

In a study of eight food-deprived healthy volunteers, ibutamoren reversed protein reduction that could cause muscle wasting.

In 123 older patients with hip fracture, ibutamoren improved gait speed and muscle strength and reduced the number of drops.

3) Increases Bone Density

Growth hormone (GH) increases bone turnover and finally bone density. But because of the increased turnover in areas treated with growth hormone, bone density could initially fall before increasing.

Essentially, it takes time (over a year) to see bone density growth.

In 24 healthy obese male volunteers, ibutamoren increased bone regeneration.

In three clinical trials of 187 older adults (65+ years), ibutamoren increased bone building, as measured by osteocalcin, a marker of bone turnover.

In one research with 292 postmenopausal women, ibutamoren improved bone mineral density, which helps increase bone strength and can be considered to reduce osteoporosis.

These initial studies show some promise, but they are not of high enough quality to establish a benefit to bone density. Future clinical trials can provide additional evidence and shine a light on almost any adverse side effects.

Ibutamoren improves bone mineral density in the long term, even though it may initially lower it because of increased bone regeneration. However, evidence of the result is still considered inadequate.

4) Improves Sleep Quality

A small, restricted study showed that at both younger and elderly subjects, ibutamoren enhanced sleep caliber and REM (rapid eye movement) sleep length.

Apart from scientific studies, there have been a number of reports of improved sleep quality across online forums. However, these reports may be due to a placebo effect. User experiences are never enough evidence to attempt potentially dangerous unapproved drugs.

5) May Promote Longevity

Growth Hormone (GH) secretion and muscle density both decline from mid-puberty throughout life.

In a study with 65 older adults, daily ibutamoren increased GH and IGF-1 amounts to those of healthy young adults with no severe negative effects.

IGF-1 is supposed to have beneficial results on longevity.

In another study with 24 obese men (double-blind randomized controlled trial), ibutamoren rejuvenated the growth hormone profile.

Ibutamoren’s potential impact on lifespan remains under investigation. Current available studies are small and of relatively low quality; they’re considered too small to establish a benefit, especially given the unknown safety profile of this medication.

Ibutamoren will promote longevity by increasing growth hormone and IGF-1. However, this potential advantage is based on quite small, low carb studies.

6) Nootropic Outcomes

Some folks use ibutamoren because of nootropic since it functions on the ghrelin receptor, which includes nootropic effects. You may read more about those effects in the post on ghrelin. Science is, however, yet to ascertain if and how ibutamoren influences cognitive performance.

Two indirect mechanisms by which ibutamoren can improve brain function include:

• Increasing IGF-1, that enhances learning and memory
• Boosting REM sleep duration and sleep quality, that Is Vital for cognitive function

The research questioned the institution of low IGF-1 and Alzheimer’s disease, and if ibutamoren could help. However, in this study, ibutamoren was ineffective at slowing the progression of Alzheimer’s in people.

Some users claim ibutamoren has nootropic effects. It might increase cognition by improving sleep quality and raising IGF-1, but the one clinical trial testing this theory found no nootropic benefit.

7) Combats Growing Hormone Deficiency

Ibutamoren can increase growth hormone, IGF-1, and IGFBP-3 levels in children with growth hormone deficiency without altering the concentrations of prolactin, glucose, triiodothyronine (T3), thyroxine (T4), thyrotropin, insulin or cortisol.

It had an identical impact on severely GH-deficient men, but glucose and insulin increased, too.

8) May Support Wound Healing and Tissue Regeneration

The growth hormone increases tissue regeneration and wound healing, therefore ibutamoren might aid with these.

There are reports of ibutamoren being helpful, but scientific research is lacking.

Negative Effects

Comprehensive clinical testing is needed to determine the side effects of a drug, and ibutamoren hasn’t undergone such testing. Thus, ibutamoren might have additional (potentially severe) side effects that have been uncovered. That’s why we say you shouldn’t take this medication: we do not know enough about its security profile.

That said, the most typical side effects of ibutamoren from the existing literature are increased appetite, moderate lower extremity edema, and muscle pain.

Several studies report an increase in fasting blood glucose and a decrease in insulin sensitivity.

These side effects are very similar to those detected in people with elevated growth hormone levels, mainly joint pain and insulin resistance.

Though most studies report little or no side effects, 1 study was terminated due to severe adverse events. That is a big deal and usually a sign that investigators believed the chemical really harmful. Stopping a clinical trial because of adverse events is a giant red flag and a very good motive not to take the chemical in question.

In older patients with hip fracture, ibutamoren raised blood pressure, blood sugar and HbA1c, and there were cases of congestive heart failure. The patients who experienced congestive heart failure were more than 80 and had a history of previous heart failure.

It would be prudent not to take ibutamoren due to these dangers.

As an anabolic, ibutamoren ought to be avoided if you have cancer. Both growth hormone and IGF-1 can promote cancer development.

We would not recommend taking ibutamoren for any reason, but particularly if you’re Th1 dominant because the growth hormone has immune-stimulatory properties.

Ibutamoren might lead to muscle strain and heart failure. It can raise blood glucose, appetite, insulin resistance, blood pressure, and cancer growth. Small and limited studies have already found serious adverse events, indicating that this is an unsafe compound.

Takeaway

Ibutamoren is an unapproved medication that may boost growth hormone (GH) and IGF-1. Unlike other GH stimulators, it may be taken orally, once per day. Bodybuilders use ibutamoren to build muscle and eliminate fat. Some people assert that ibutamoren can also improve bone density, sleep, and cognitive functioning, but there are not any studies to back up this. Ibutamoren may lead to leg swelling, muscle pain, and insulin resistance. In rare situations, it may raise blood pressure and cause heart failure. Cancer patients should avoid ibutamoren, since it may feed the growth of tumors. Clinical trials have, thus far, been too small to reliably identify adverse consequences; the safety profile of ibutamoren is thus incomplete. We recommend strongly against accepting ibutamoren for any reason.